Novel Study Provides Additional Proof That Cannabis Decrease Tumor Development
The most important psychoactive element in cannabis – tetrahydrocannabinol – could be applied to cut down tumor development in cancer sufferers, with respect to an international research team.
Earlier research have recommended that cannabinoids, of which tetrahydrocannabinol (THC) is one, have anti cancer components. In 2009, scientists at Complutense University identified that THC stimulated the death of brain cancer cells in a procedure well-known as “autophagy.”
The scientists identified that giving THC to mice with human tumors started autophagy and caused the development of the tumors to reduce. Two human sufferers with highly aggressive brain tumors who obtained intracranial administration of THC also demonstrated similar signs of autophagy, upon examination.
The group behind the new research – co-lead by Complutense University and the University of Anglia (UEA) – claims to have identified earlier unknown “signaling platforms” that enable THC to reduce tumors.
The scientists stimulated tumors in mice making use of samples of human breast cancer cells. When the tumors were aimed with doses of THC, the scientists identified that two cell receptors were especially related with an anti tumor reaction.
Dr. Peter McCormick states that “THC, the primary active element of marijuana, has anti-cancer qualities. This ingredient is identified to act via a particular family of cell receptors known as cannabinoid receptors.”
“We show that these results are mediated through the joint connections of CB2 and GPR55 – 2 members of the cannabinoid receptor family. Our results assist describe some of the well known but still improperly understood effects of THC at low and high doses on tumor development.”
However, the team is not sure which receptor is the most accountable for the anti-tumor properties.
Dr. McCormick states that there has been a “great deal of fascination” in knowing the molecular mechanisms regarding how marijuana impacts cancer pathology. This has been associated by a drive in the pharmaceutical sector to synthesize a medical version of the drug that maintains the anti-cancer effects. By determining the receptors engaged we have offered an essential step towards the upcoming development of therapeutics that can get benefits of the connections we have identified to decrease tumor growth.
Why individuals should not ‘self medicate’ with Cannabis
Cancer sufferers should not be tempted to self-medicate, Dr. McCormick alerts:
“Our study uses an isolated chemical substance and using the appropriate concentration is important. Cancer sufferers should not use cannabis to self medicate, but I wish that our research will guide to a safe synthetic equivalent being accessible in the long run.”
Cannabis not only has positive effects but also some negative effects, recently Clinical Research Society reported How cannabis leads to Paranoia.