Thanks for sharing the article. It is a comprehensive write up of one who has experienced and analysed what Note to file is all about.
It is a must to read document for all those invlolved in clinical trials. (My personal suggestion)
As truly quoted, Note to files, in today's situation has been an aid for site personnel as well as the CRA's to document a mistake, which does not serve any purpose.
Use of Note to File has to be very judicious and Not for anything and everything the CRA or site personnel feels like to document to safeguard one's mistake during audit.
Thanks & regards