Now scenario is changing slightly and what I have seen like few sponsors has taken the initiative and they developed their own Clinical Research team with SOPs and all for conduct of the trials. So if you are talking about the CRA for such sponsor then the job profile is same as what we used to do from Site Selection to Site close out, all the activities we need to perform as a CRA on behalf of Sponsor.
If you are talking about the Collaborative study with CRO & Sponsor then generally what a Sponsor's CRA used to do is he will be the link between a Sponsor and CRO. So he will check the reports and all on behalf of sponsor, he will manage the shipments and study supplies requested by a Site CRA from Sponsor's end then he will come for the initiation visit to check weather all important aspect of the study is been explained or not.
So his task is basically to act of oversee a Site CRA's work and check weather the study is been conducted properly or not and he will report to the Senior management of sponsor about the study progress.